The railway lines between Swindon and Gloucester have been closed.
A train collided with a car on a level crossing in Frampton Mansell at around 3.10pm.
British Transport Police say a man has been killed in the crash.
Officers from BTP attended alongside paramedics from the South Western Ambulance Service however a man, believed to be the driver of the car, was sadly pronounced dead at the scene.
The car was struck by the Great Western Railway’s London Paddington to Cheltenham Spa service. There are no other reported injuries.
At present, officers are currently examining the scene to establish the circumstances which led to the man’s car being struck.
The Rail Accident Investigation Branch have been notified of this incident.
Anyone with any information is asked to contact BTP by calling 0800 40 50 40 quoting reference 311 of 07/02. Or you can send a text to BTP on 61016.